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Updated: Sep 21, 2026

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
Published on: February 10, 2015
Hodgkin's disease presenting as cholestatic hepatitis with prominent ductal injury
Suthat Liangpunsakul1, Paul Kwo, George K Koukoulis
1Department of Medicine, Division of Gastroenterology and Hepatology, Indiana School of Medicine, Indianapolis, Indiana, USA. sliangpu@iupui.edu
Abstract:
In advanced stages of Hodgkin's disease, liver involvement is common. However, Hodgkin's disease mimicking cholestatic hepatitis at presentation is rare. We describe a patient with Hodgkin's disease who was initially considered to have acute cholestatic hepatitis. Liver biopsy demonstrated prominent bile duct injury associated with a florid inflammatory reaction. These changes may represent an early stage of ductal injury, subsequently leading to vanishing bile duct syndrome, a recently documented mechanism of cholestasis in Hodgkin's disease.
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