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Is there a dose response relationship for clodronate in the treatment of tumour induced hypercalcaemia?
1Department of Palliative Medicine, The Royal Marsden NHS Trust, Sutton SM2 5PT, Surrey, UK.
Abstract:
Eighty-six patients with tumour induced hypercalcaemia were randomised to 600, 900, 1200 or 1500 mg of intravenous clodronate, according to post hydration serum calcium levels. Sixty-seven were evaluable for response. The overall response rate was 49.3% (95% CI: 36.8-61.8) with no significant difference in response rates, i.e. achievement of normocalcaemia at days 6-9 (corrected serum calcium < or =2.6 mmol l(-1)) across all groups.
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