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DNA profiles and numeric histogram classifiers in nephrogenic adenoma.

Helene G Wiener1, Gerard W Remkes, Peter Birner

  • 1Department of Clinical Pathology, University of Vienna, Vienna, Austria. Helene.Wiener@akh-wien.ac.at

Cancer
|April 16, 2002
PubMed
Summary

Image cytometry DNA analysis can distinguish bladder lesions, identifying those with higher malignant potential. The 2c deviation index is superior for classifying nephrogenic adenoma and papillary urothelial carcinoma.

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Area of Science:

  • Uropathology
  • Oncology
  • Medical Imaging

Background:

  • Nephrogenic adenoma's malignant potential remains debated, with varied treatment approaches.
  • Accurate classification is crucial for determining appropriate therapeutic strategies.

Purpose of the Study:

  • Evaluate DNA histogram classifiers for distinguishing nephrogenic adenoma from lesions with higher malignant potential.
  • Identify image cytometry features differentiating nonaggressive from potentially aggressive lesions.

Main Methods:

  • Analyzed DNA histograms from bladder irrigation specimens using static image analysis.
  • Included specimens from nephrogenic adenoma and papillary bladder carcinoma resections.
  • Utilized DNA index, 2c deviation index, 5c/9c-exceeding rates, and a dual-parameter algorithm.

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Main Results:

  • Nephrogenic adenoma showed low proliferative activity (DNA indices 0.91-1.15, 2c deviation 0.03-0.43).
  • The 2c deviation index ranges for nephrogenic adenoma and papillary urothelial carcinoma did not overlap.
  • High risk was associated with nephrogenic adenomas in patients with prior transitional cell carcinoma history.

Conclusions:

  • Image cytometry DNA analysis of bladder irrigation specimens can differentiate papillary lesions.
  • The method effectively identifies higher-risk lesions but has limitations for low-risk entities.
  • The 2c deviation index demonstrated superior discriminative power compared to DNA index and 5c exceeding rate.