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Related Experiment Videos

Thromboembolic complications after total hip replacement.

B Borghi1, A Casati,

  • 1Department of Anaesthesiology, IRCCS Rizzoli Orthopaedic Institute, Bologna, Italy.

International Orthopaedics
|April 17, 2002
PubMed
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Low-molecular-weight heparin and indobufen were more effective than unfractionated heparin in preventing deep vein thrombosis after hip replacement surgery. Cemented hip arthroplasty was associated with a higher risk of pulmonary embolism.

Area of Science:

  • Orthopedic Surgery
  • Vascular Surgery
  • Pharmacology

Background:

  • Total hip replacement is a common surgical procedure.
  • Thromboembolic complications, such as deep vein thrombosis (DVT) and pulmonary embolism (PE), are significant risks following hip surgery.
  • Prophylactic anticoagulation strategies aim to mitigate these risks.

Purpose of the Study:

  • To compare the efficacy of three different thromboembolic prophylactic regimens in patients undergoing total hip replacement.
  • To evaluate the incidence of symptomatic DVT and PE in patients receiving unfractionated heparin (UFH), low-molecular-weight heparin (LMWH), or indobufen (INDO).

Main Methods:

  • Retrospective analysis of 1,640 patients undergoing total hip replacement between 1990 and 1997.
  • Patients received prophylactic regimens of UFH, LMWH, or INDO.

Related Experiment Videos

  • Postoperative symptomatic DVT and PE were recorded within 30 days and at follow-up.

    • Main Results:

    • The incidence of symptomatic DVT was significantly higher in patients receiving UFH (3.6%) compared to LMWH (1.3%) or INDO (0.3%) (OR=6.05, P=0.001).
    • The incidence of PE was higher in patients receiving cemented hip arthroplasty (2.4%) versus uncemented hip arthroplasty (0.34%) (OR=3.185, P=0.05).

    Conclusions:

    • LMWH and INDO demonstrate superior efficacy over UFH in preventing symptomatic DVT after total hip replacement.
    • Cemented hip arthroplasty is associated with an increased risk of PE compared to uncemented procedures.