Related Experiment Video
Updated: Oct 1, 2026

Examination of Oral Candida Infection in Primary Sjögren's Syndrome Patients
Published on: March 1, 2024
Thrombotic thrombocytopenic purpura as an initial presentation of primary Sjögren's syndrome
A Schattner1, J Friedman, A Klepfish
1Kaplan Medical Center, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
Abstract:
A healthy woman presented with ecchymoses due to thrombocytopenia, with numerous bone marrow megakaryocytes, microangiopathic haemolytic anaemia, disorientation, irritability, and normal renal function. Thrombotic thrombocytopenic purpura (TTP) was diagnosed and treated successfully by plasma exchange therapy, both on presentation and during a further three relapses. The TTP was considered idiopathic until, 4 months later, definite primary Sjogren's syndrome (1 degree SS) was diagnosed following the appearance of sicca symptoms. Only four similar cases have been cited in the literature. TTP should be added to the varied haematological manifestations that may occur in patients with 1 degree SS. The possible presentation of 1 degree SS not with classic sicca symptoms but rather with haematological abnormalities, including TTP, should be recognised.
Related Concept Videos
Nephrotic Syndrome I : Introduction
Inflammatory Bowel Disease IV: Clinical Manifestations
Endocarditis II: Clinical Features of Infective Endocarditis
Graves' Disease I: Introduction
Myasthenia Gravis ll: Pathophysiology
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies
