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Related Concept Videos

Olfaction01:25

Olfaction

The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
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Background and Environment Affect Phenotype

Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
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Physiology of Smell and Olfactory Pathway

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The olfactory...

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Related Experiment Video

Updated: Jun 30, 2026

Imaging Pheromone Sensing in a Mouse Vomeronasal Acute Tissue Slice Preparation
09:31

Imaging Pheromone Sensing in a Mouse Vomeronasal Acute Tissue Slice Preparation

Published on: December 6, 2011

Pheromones, vomeronasal function, and gender-specific behavior.

Eric B Keverne1

  • 1Sub-Department of Animal Behaviour, University of Cambridge, Madingley, CB3 8AA, Cambridge, United Kingdom. ebk10@cus.cam.ac.uk

Cell
|April 17, 2002
PubMed
Summary
This summary is machine-generated.

Mice without the TRP2 ion channel show distinct behaviors, revealing the vomeronasal organ's crucial role in sex-specific social interactions and reproduction.

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In-depth Physiological Analysis of Defined Cell Populations in Acute Tissue Slices of the Mouse Vomeronasal Organ

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Related Experiment Videos

Last Updated: Jun 30, 2026

Imaging Pheromone Sensing in a Mouse Vomeronasal Acute Tissue Slice Preparation
09:31

Imaging Pheromone Sensing in a Mouse Vomeronasal Acute Tissue Slice Preparation

Published on: December 6, 2011

Imaging Neuronal Responses in Slice Preparations of Vomeronasal Organ Expressing a Genetically Encoded Calcium Sensor
11:26

Imaging Neuronal Responses in Slice Preparations of Vomeronasal Organ Expressing a Genetically Encoded Calcium Sensor

Published on: December 6, 2011

In-depth Physiological Analysis of Defined Cell Populations in Acute Tissue Slices of the Mouse Vomeronasal Organ
10:11

In-depth Physiological Analysis of Defined Cell Populations in Acute Tissue Slices of the Mouse Vomeronasal Organ

Published on: September 10, 2016

Area of Science:

  • Neuroscience
  • Behavioral Biology
  • Sensory Systems

Background:

  • The vomeronasal organ (VNO) is a sensory structure implicated in detecting pheromones.
  • TRP2 ion channels are expressed in the VNO and are crucial for sensory transduction.

Purpose of the Study:

  • To investigate the role of the TRP2 ion channel in the function of the vomeronasal organ.
  • To elucidate the contribution of the VNO and TRP2 to gender-specific sexual behaviors in mice.

Main Methods:

  • Behavioral analysis of mice lacking the TRP2 ion channel (TRP2 knockout mice).
  • Assessment of social and sexual behaviors in controlled experimental settings.

Main Results:

  • TRP2 knockout mice exhibit significantly altered gender-specific sexual behaviors compared to wild-type controls.
  • These behavioral deficits highlight the critical role of VNO-mediated sensory input in regulating reproductive behaviors.

Conclusions:

  • The TRP2 ion channel is essential for normal vomeronasal organ function.
  • Vomeronasal organ signaling, mediated by TRP2, is indispensable for the precise execution of gender-specific sexual behaviors.