Related Experiment Video
Updated: Jul 11, 2026
05:53
Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
Research in complex diseases
Niek de Vries1, Piet L C M van Riel, Leo B A van de Putte
1Department of Rheumatology and Clinical Immunology, University Medical Centre, Utrecht, Netherlands. N.deVries@medonline.nl
Lancet (London, England)
|April 17, 2002
Summary
This study outlines research goals for complex diseases like atherosclerosis and diabetes. It proposes a stepwise approach to developing disease models, considering genetic and random factors.
Area of Science:
- Biomedical Research
- Disease Modeling
- Genetics
Background:
- Complex diseases such as atherosclerosis, diabetes mellitus, and rheumatoid arthritis significantly impact public health.
- Understanding the pathogenesis of these diseases is crucial for developing effective treatments.
Purpose of the Study:
- To discuss a hierarchy of research goals for complex diseases.
- To introduce a stepwise approach for developing disease models.
- To emphasize the role of genetic factors and stochastic variables in these models.
Main Methods:
- Literature review and conceptual framework development.
- Discussion of research objectives and model development strategies.
- Analysis of the influence of genetic and stochastic elements.
Main Results:
- A structured hierarchy of research goals for complex diseases is presented.
- A stepwise methodology for constructing disease models is proposed.
- The integration of genetic predispositions and random variables in modeling is highlighted.
Conclusions:
- A systematic approach to studying complex diseases is essential.
- Accurate disease models require the incorporation of genetic and stochastic components.
- This framework aids in advancing research on multifactorial health conditions.
More Related Videos
Related Concept Videos
01:05Single Nucleotide Polymorphisms-SNPs
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
01:18Factors Affecting Illness
When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness, disability,...
For instance, risk factors are connected to illness, disability,...
01:27Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Medical History
01:22Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
01:23Investigation of Disease Outbreaks
Multistate foodborne outbreaks pose significant public health risks and require meticulous investigation to identify sources and implement control measures. The Centers for Disease Control and Prevention (CDC) utilizes a dynamic seven-step process for these investigations, integrating data from laboratories, interviews, and environmental assessments to protect public health.Outbreak Detection: The detection of multistate outbreaks typically begins with PulseNet, the CDC's national laboratory...