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Vasculitis due to gemcitabine
A M C J Voorburg1, F T van Beek, P H Th J Slee
1Department of Pulmonology, St. Antonius Hospital Nieuwegein, PO Box: 2500, 3430 CM, The Netherlands.
Abstract:
We report the first occurrence of gemcitabine-induced vasculitis. It concerns a 45-year-old man diagnosed with non-small lung cancer since 2 months. After the first cycle of chemotherapy, consisting of gemcitabine and cisplatin, he developed myalgia and swelling of arms and legs with impairment of movement. This re-occurred during the second cycle of chemotherapy. Further anemia, elevated ESR and increased creatininephosphokinase. A surgical biopsy showed leucocytoclastic vasculitis and necrosis of muscle tissue. The chemotherapy was stopped and the complaints disappeared and did not return.