[Effect of D-penicillamine on the humoral primary response (author's transl)]

The influence of D-penicillamine (Pen) on the humoral primary response was studied systematically. Inbred rats are sensitized with erythrocytes of mice of one strain. Pen given at various schedules (dosage: 3 X 100 resp. 3 X 1000 mg/kg at 24 h intervals) showed no effect on antibody titer 7 days after sensitization. When Pen is given before the antigen the slope of the titer after day 7 is accelerated. Compared to experiments with alkylating drugs and antimetabolites in the same model Pen does not show immunosuppressive potency.