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Hemolytic uremic syndrome due to an altered factor H triggered by neonatal pertussis
Reinhard Berner1, Martin F Krause, Nader Gordjani
1University Children's Hospital, Mathildenstrasse 1, 79106 Freiburg, Germany. berner@kikli.ukl.uni-freiburg.de
Pediatric Nephrology (Berlin, Germany)
|April 17, 2002
Abstract:
We report on a previously healthy newborn suffering from severe Bordetella pertussis infection who developed hemolytic uremic syndrome (HUS) a few weeks after the onset of whooping cough, with a fatal outcome. A factor H protein with abnormal mobility was found in the serum of the patient as analyzed by Western blotting, indicating that B. pertussis infection might have triggered HUS in a genetically predisposed patient.