[Pathological dominant and determinant in pathogenesis of nervous and mental disorders]

The dominant (A.A. Ukhtomsky) and the determinant (G.N. Kryzhanovsky) are different working principles and basic mechanisms underlying nervous system function in health and disease. The main feature of the dominant is related inhibition of other structures or systems. This inhibition provides normal functioning of physiological system, which is dominant at the given time. The pathology of the dominant relationships consists in insufficient or excessive coupled inhibition. The structures which determine and form a corresponding functional premise to the efferent system structures for achieving the present result play a role of the determinant in physiological system. The role of the pathological determinant is performed by hyperactive CNS structure which determines a functional state of other structures connected with it and forms, along with them, a pathological system underlying the corresponding neuropathological syndrome.