[A evolutionary approach to identification of orthologous relationship across proteomes]

How to identify the true orthologous and paralogous relationships among protein families is still a key problem in genome annotation and comparative protemics. Here, a evolutionary approach to ascertainment of the orthologous relationships across the genomes is developed. Forty-four cases of protein families are used in the test for the evolutionary approach. Compared with the method of COG (cluster of orthologous groups of proteins), this approach can generally identify the orthologous relationships and accurately predict the genome function.