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Small and large artery elasticity indices in peripheral arterial occlusive disease (PAOD)

D A Duprez1, M M L De Buyzere, L De Bruyne

  • 1Cardiovascular Division, University Hospital, Ghent, Belgium. Daniel.Duprez@rug.ac.be

Vascular Medicine (London, England)
|April 18, 2002
PubMed

Insights

Peripheral arterial occlusive disease (PAOD) shows reduced large and small artery elasticity, similar to controls. Arterial elasticity indices correlate with disease severity markers like ankle-brachial index and pulse pressure.

Area of Science:

  • Vascular Biology
  • Cardiovascular Physiology
  • Medical Diagnostics

Background:

  • Peripheral arterial occlusive disease (PAOD) is associated with reduced central arterial compliance.
  • The impact of PAOD on peripheral arterial compliance remains unclear.

Purpose of the Study:

  • To determine large (C1) and small (C2) artery elasticity indices in PAOD patients.
  • To investigate the relationship between arterial elasticity and established PAOD characteristics (ABI, PP, ACD).

Main Methods:

  • Non-invasive pulse wave analysis using a modified Windkessel model.
  • Measurement of large artery elasticity (C1) and small artery elasticity (C2).
  • Comparison of elasticity indices between 43 PAOD patients and 16 age/BP-matched controls.

Main Results:

  • Both C1 and C2 values in PAOD patients were comparable to the control group.
  • C1 showed significant correlations with absolute claudication distance (ACD) and pulse pressure (PP).
  • C2 correlated with pulse pressure (PP) and ankle-brachial index (ABI), but not ACD.

Conclusions:

  • Large and small artery elasticity indices in PAOD are reduced but comparable to elderly individuals with isolated systolic hypertension.
  • Arterial elasticity indices (C1 and C2) correlate with markers of vascular disease severity (ABI and PP).

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