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Malignant eccrine spiradenoma.

Imran Mirza1, Robert Kloss, Steven C Sieber

  • 1Department of Pathology, Danbury Hospital, Danbury, CT 06810, USA.

Archives of Pathology & Laboratory Medicine
|April 18, 2002
PubMed
Summary
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Malignant eccrine spiradenoma, a rare cancer, was successfully treated with surgery and hormonal therapy in a 70-year-old man. This case highlights the importance of surgical management and suggests potential benefits of endocrine treatment for this rare tumor.

Area of Science:

  • Dermatology
  • Surgical Oncology
  • Endocrinology

Background:

  • Eccrine spiradenoma is a benign adnexal tumor.
  • Malignant transformation of eccrine spiradenoma is exceptionally rare.
  • Metastasis from eccrine spiradenoma is uncommon.

Observation:

  • A 70-year-old male presented with malignant eccrine spiradenoma of the forearm.
  • The tumor had metastasized to the axillary lymph nodes.
  • Immunostaining confirmed estrogen receptor positivity.

Findings:

  • The patient underwent surgical excision with adequate margins and axillary lymph node dissection.
  • Adjuvant tamoxifen therapy was initiated due to estrogen receptor positivity.
  • After 41 months of follow-up, no recurrence or distant metastasis was observed.

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Implications:

  • Wide local excision and vigilant follow-up are essential for managing malignant eccrine spiradenoma.
  • Hormonal therapy may play a role in the adjuvant treatment of this rare malignancy.
  • Further research is needed to establish the definitive role of hormonal and other therapeutic modalities.