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Galanin-like peptide stimulates food intake in the rat
Yoshio Matsumoto1, Takuya Watanabe, Yuka Adachi
1Pharmaceutical Research Division, Takeda Chemical Industries Ltd., Jusohonmachi 2-17-85, Yodogawa, Osaka, 532-8686, Japan.
Neuroscience Letters
|April 18, 2002
Abstract:
We have isolated a novel hypothalamic peptide, Galanin-like peptide (GALP), as a ligand for galanin receptor subtype GalR2. To investigate the physiological role of GALP, we examined the effect of the intracerebroventricular administration of GALP and found that GALP induced food intakes. GALP had ten-fold the orexigenic activity of galanin. We also observed the anxiogenic-like behavior after the administration of 1 nmol GALP. These results suggest that GALP is a novel orexigenic and anxiogenic peptide.