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Design, synthesis and bioactivity evaluation of tribactam beta lactamase inhibitors
Anton Copar1, Tadeja Prevec, Borut Anzic
1Lek d.d., Research and Development, Celovska 135, 1526, Ljubljana, Slovenia.
Bioorganic & Medicinal Chemistry Letters
|April 18, 2002
Abstract:
Known carbapenem compounds with inhibitory effect towards beta-lactamase enzymes are formed from bicyclical beta lactam structural scaffolds. On the basis of results from theoretical computational methods and molecular modelling we have designed and developed a synthetic route towards novel, biologically active tricyclic derivatives of carbapenems.