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Binding properties of oligonucleotides containing a modified 2'-deoxyuridine with a thymine ended linker to pair with
Pascal Savy1, Rachid Benhida, Jean Louis Fourrey
1Institut de Chimie des Substances Naturelles, CNRS, 91198, Gif-sur-Yvette, France.
Bioorganic & Medicinal Chemistry Letters
|April 18, 2002
Abstract:
Oligonucleotides containing in the place of thymidine the nucleoside 2, a 2'-deoxyuridine harbouring at C-5 a thymine ended linker, were found to undergo base pairing with the opposite 2'-deoxyadenosine. However, the corresponding duplexes are significantly destabilised as compared to the fully natural ones.