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Normal aging in the central nervous system: quantitative MR diffusion-tensor analysis.

Osamu Abe1, Shigeki Aoki, Naoto Hayashi

  • 1Department of Radiology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8655 Tokyo, Japan. abediag-tky@umin.ac.jp

Neurobiology of Aging
|April 18, 2002
PubMed
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Normal aging alters brain diffusion metrics. Mean diffusivity (ADC) increases in frontal white matter and lentiform nucleus, while fractional anisotropy (FA) decreases in the genu of the corpus callosum.

Area of Science:

  • Neuroimaging
  • Radiology
  • Gerontology

Background:

  • Normal aging is associated with structural and functional changes in the central nervous system.
  • Diffusion Tensor Imaging (DTI) is a sensitive MRI technique for evaluating white matter integrity.
  • Understanding age-related changes in brain diffusion metrics is crucial for distinguishing normal aging from neurodegenerative diseases.

Purpose of the Study:

  • To investigate changes in mean diffusivity (ADC) and fractional anisotropy (FA) in the central nervous system during normal aging using MR diffusion tensor imaging (DTI).
  • To establish normative DTI values for different brain regions in a healthy aging population.
  • To provide a baseline for comparison with pathological aging processes.

Main Methods:

  • Fifty healthy volunteers (30 men, 20 women; age range 21-69 years) underwent MR DTI.

Related Experiment Videos

  • Regions of interest included frontal white matter, parietal white matter, lentiform nucleus, posterior limb of internal capsule, thalamus, genu and splenium of the corpus callosum.
  • Analysis focused on changes in ADC and FA with advancing age, stratified by sex and hemisphere.

    • Main Results:

    • No significant differences in ADC or FA were found between sexes or between the right and left hemispheres.
    • A significant increase in ADC was observed with advancing age in the frontal white matter (P=0.010) and lentiform nucleus (P=0.022).
    • A significant decline in FA was observed with advancing age exclusively in the genu of the corpus callosum (P<0.001).

    Conclusions:

    • Quantitative DTI analysis can effectively correlate with normal aging processes in the brain.
    • These findings provide valuable insights into age-related microstructural changes in the central nervous system.
    • This study establishes a standard for assessing normal aging and aids in the differential diagnosis of neurodegenerative disorders.