Deriving folds of macromolecular complexes through electron cryomicroscopy and bioinformatics approaches
Wah Chiu1, Matthew L Baker, Wen Jiang
1Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA. wah@bcm.tmc.edu
Current Opinion in Structural Biology
|April 18, 2002
Abstract:
Intermediate-resolution (7-9A) structures of large macromolecular complexes can be obtained by electron cryomicroscopy. This structural information, combined with bioinformatics data for the individual protein components or domains, can lead to a fold model for the entire complex. Such approaches have been demonstrated with the 6.8 A structure of the rice dwarf virus to derive models for the major capsid shell proteins.
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