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Naïve to memory T-cell differentiation during homeostasis-driven proliferation

Qing Ge1, Hui Hu, Herman N Eisen

  • 1Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, E17-128, 40 Ames Street, Cambridge, MA 02139, USA.

Microbes and Infection
|April 18, 2002
PubMed

During homeostasis-driven T-cell proliferation, naïve T cells stably acquire the cell surface markers and functional properties of antigen-induced memory T cells. Thus, in T-cell-deficient individuals, homeostasis-driven T-cell proliferation appears to restore only the memory T-cell compartment, whereas the reconstitution of the naïve T-cell compartment depends on de novo T-cell development in the thymus.

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