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Association between IL-4 genotype and IL-4 production in the Japanese population
H Nakashima1, K Miyake, Y Inoue
1Department of Medicine and Biosystemic Science, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan. hnakashi@intmed1.med.kyushu-u.ac.jp
Genes and Immunity
|April 18, 2002
Abstract:
We have identified that there are only two IL-4 gene haplotypes (I and II) in the Japanese population. There are significant differences among three genotypes (I/I, I/II and II/II) in the IL-4 producing proportion of peripheral Th cells using intracellular cytokine detection assay. These results make it likely that IL-4 genotype could influence the type of immune response.