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3-O-substituted benzyl pyridazinone derivatives as COX inhibitors
Vamsee Krishna Chintakunta1, Venkateswarlu Akella, Manohar Sharma Vedula
1Discovery Chemistry, Dr. Reddy's Research Foundation, Bollaram Road, Miyapur, Hyderabad 500050, India.
European Journal of Medicinal Chemistry
|April 19, 2002
Abstract:
New 3-O-substituted benzyl pyridazinone compounds have been synthesised and evaluated for their cyclooxygenase inhibitory activity and COX-2 selectivity. Among the compounds synthesised, three compounds (11b-11d) have shown in vitro COX-2 selectivity. These compounds have been evaluated for their in vivo potential using carrageenan-induced rat paw edema assay. One compound (11b) showed 32% anti-inflammatory activity at 30 mgkg(-1) dose.