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Synthesis and immunofluorescence assay of a new biotinylated paclitaxel
Thota Sambaiah1, Ke Yung King, Shwu Chen Tsay
1Department of Chemistry, Organosilicon and Synthesis Laboratory, National Tsing Hua University, Hsinchu 30013, Taiwan, ROC.
European Journal of Medicinal Chemistry
|April 19, 2002
Abstract:
7-(5'-Biotinylamidopropanoyl)paclitaxel was synthesised by chemical methods; its immunofluorescence assay and the cell uptake experiments were performed by use of human leukemia U937 cells. The results indicate that paclitaxel is arresting cell cycle at the G(2)M phase only.