Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Environmental stress mediates changes in neuroimmunological interactions.

Elliot M Friedman1, David A Lawrence

  • 1Laboratory of Clinical and Experimental Endocrinology and Immunology, Wadsworth Center, Albany, New York 12201, USA.

Toxicological Sciences : an Official Journal of the Society of Toxicology
|April 19, 2002
PubMed
Summary

Environmental stress, including chemical, physical, and psychological factors, significantly impacts health by altering neuroendocrine immune pathways. Understanding these combined stressors and individual genetic variations is crucial for assessing health risks.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Accentuating the Positive: Contribution of Positive Relations With Others and Daily Interpersonal Interactions to Longevity.

Biopsychosocial science and medicine·2026
Same author

Prenatal exposure to phthalates, maternal oxidative stress, and early childhood neurobehavior: a pathway modeling approach.

Environmental research·2026
Same author

Integrating exposomics and multi-omics with dysbiosis biomarkers for clinical and environmental connections implicated in neuropathology. Cause and cure cluses.

Toxicological sciences : an official journal of the Society of Toxicology·2026
Same author

Preparation of Human Lymphocyte Proteins to Profile Targets of Oxidative Stress.

Current protocols·2026
Same author

Poorer subjective hearing is associated with less frequent and more negative social interactions in older adults.

The journals of gerontology. Series B, Psychological sciences and social sciences·2025
Same author

Mitochondrion-Mediated Metabolism and Microbiome Biodiversity Influence Autism-alike Behaviors.

Journal of neurology & translational neuroscience·2025

Area of Science:

  • Environmental toxicology
  • Neuroimmunology
  • Health risk assessment

Background:

  • Environmental stress, encompassing chemical, physical, and psychological factors, poses significant toxicological risks to health.
  • Individual genetic variations modulate susceptibility to environmental exposures.
  • Existing research often overlooks the combined impact of multiple stressors on health outcomes.

Purpose of the Study:

  • To review the interplay between neural, endocrine, and immune systems under combined environmental stress.
  • To emphasize the role of psychological stress in modulating health outcomes.
  • To highlight the need for integrated approaches in toxicological and epidemiological studies.

Main Methods:

  • Review of existing animal and human studies.

Related Experiment Videos

  • Analysis of neuroendocrine immune circuitry.
  • Focus on regulatory pathways influenced by psychological stress.

    • Main Results:

    • Combined environmental stressors can exacerbate illness initiation and duration.
    • Detrimental health outcomes are linked to alterations in neuroendocrine immune function.
    • Psychosocial environment significantly influences individual exposure outcomes.

    Conclusions:

    • Neuroimmunology research must incorporate the effects of combined stressors and psychological stress.
    • Future studies should investigate the bidirectional regulatory mechanisms between neural, endocrine, and immune systems.
    • A comprehensive understanding of "real world" exposures requires considering chemical mixtures alongside physical and psychological factors.