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Frequency of factor V, prothrombin and methylenetetrahydrofolate reductase gene variants in preeclampsia
Angela V D'Elia1, Lorenza Driul, Roberta Giacomello
1Department of Biomedical Science and Technology, University of Udine, Udine, Italy.
Background:
The association between thrombophilic variants (Leiden mutation of the factor V gene, G20210A mutation of the prothrombin gene and C677T polymorphism of the methylenetetrahydrofolate reductase (MTHFR) gene) with preeclampsia was investigated in a north-eastern Italian population.
Methods:
Fifty-eight preeclamptic (PE) women and 74 normal pregnancies were evaluated. Genotypes were determined by polymerase chain reaction.
Results:
The frequency of heterozygous carriers of the factor V Leiden was similar between PE women (5.2%) compared to the control subjects (4.1%; p 0.76). Also the frequencies of G20210A and C677T mutations were similar between PE and control subjects.
Conclusions:
In this population, we found no difference in the prevalence of genetic risk factors for thrombosis in women with preeclampsia compared with control subjects.
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