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Urinary retinol-binding protein as a prognostic marker in glomerulopathies
Gianna Mastroianni Kirsztajn1, Sonia K Nishida, Marcelo S Silva
1Division of Nephrology, Escola Paulista de Medicina, Universidade Federal de São Paulo, Brazil. gianna@nefro.epm.br
Nephron
|April 19, 2002
Summary
Urinary retinol-binding protein (urRBP) levels can predict kidney function decline in glomerulopathies. High urRBP indicates poor prognosis, even with normal serum creatinine, aiding early intervention in kidney disease.
Area of Science:
- Nephrology
- Clinical Chemistry
Background:
- Tubulointerstitial damage significantly impacts glomerular disease progression.
- Urinary retinol-binding protein (urRBP) is a sensitive marker of proximal tubular dysfunction.
Purpose of the Study:
- To evaluate urRBP levels in various glomerulopathies (GPs).
- To correlate urRBP levels with long-term disease progression and renal function decline.
Main Methods:
- Prospective study of 238 patients with GPs.
- Measurement of urinary retinol-binding protein (urRBP).
- Longitudinal follow-up of 149 patients for up to 10 years, monitoring serum creatinine and renal function.
Main Results:
- urRBP levels varied among different glomerulopathies.
- High urRBP levels (>1 mg/l) predicted renal function loss (doubling of serum creatinine).
- This predictive value was independent and evident even with normal serum creatinine and creatinine clearance.
Conclusions:
- Urinary retinol-binding protein is a valuable, independent prognostic marker in glomerulopathies.
- Elevated urRBP can identify patients at high risk for kidney function decline.
- This test provides crucial clinical information for managing glomerulonephritis progression.