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Related Experiment Videos

Colonoscopy in mice.

E H Huang1, J J Carter, R L Whelan

  • 1Department of Surgery, College of Physicians and Surgeons, Columbia University, 161 Fort Washington Avenue, New York, NY 10032, USA. eh257@columbia.edu

Surgical Endoscopy
|April 19, 2002
PubMed
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Murine colonoscopy allows for safe, serial evaluation of the colon in mice, enabling repeated visual and histopathological examinations of the same animal for research purposes.

Area of Science:

  • Veterinary Medicine
  • Gastroenterology
  • Animal Models

Background:

  • Current murine models for colitis and colon cancer require animal sacrifice for tissue collection.
  • This limits longitudinal studies and monitoring of disease progression in individual animals.

Purpose of the Study:

  • To develop a safe and feasible colonoscopy technique for mice.
  • To enable serial endoscopic evaluation and mucosal biopsies in the same animal.

Main Methods:

  • A flexible pediatric cystoscope was used for colonoscopy in mice under anesthesia.
  • Mice received polyethylene glycol solution and were fasted prior to the procedure.
  • Biopsies were obtained from the rectosigmoid colon during examinations.

Main Results:

Related Experiment Videos

  • A total of 46 colonoscopies were performed across multiple mouse strains.
  • Minor complications occurred, with three mouse deaths unrelated to the procedure itself.
  • Small biopsies were sufficient for pathological evaluation, and transillumination aided navigation.

Conclusions:

  • Murine colonoscopy is a safe and viable technique for research.
  • This method permits repeated visual and histopathological assessments.
  • It facilitates monitoring of murine colon responses to experimental interventions.