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Related Experiment Videos

[Hyperchloremic acidosis druing plasma volume replacement].

Y Blanloeil1, B Roze, J C Rigal

  • 1Service d'anesthésie et de réanimation chirurgicale, hôpital G et R Laënnec, 44093 Nantes, France.

Annales Francaises D'Anesthesie Et De Reanimation
|April 20, 2002
PubMed
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Large volume infusions of saline can cause hyperchloraemic acidosis, a condition that resolves naturally. Using balanced solutions like lactated Ringer can prevent this metabolic acidosis.

Area of Science:

  • Physiology
  • Biochemistry
  • Critical Care Medicine

Context:

  • Plasma volume replacement is crucial in managing shock and surgical patients.
  • Crystalloid and colloid solutions are commonly used for fluid resuscitation.
  • Hyperchloraemic acidosis is a potential complication of fluid therapy.

Purpose:

  • To review the physiological and clinical consequences of hyperchloraemic acidosis during plasma volume replacement.
  • To analyze the role of crystalloids and colloids in causing this acid-base disturbance.
  • To discuss the management and prevention of hyperchloraemic acidosis.

Summary:

  • Large volume infusion of isotonic saline or saline-based colloids can induce hyperchloraemic acidosis due to excessive chloride load.
  • This condition is characterized by a normal anion gap and resolves spontaneously as chloride levels normalize.

Related Experiment Videos

  • Balanced solutions, such as lactated Ringer, are recommended over isotonic saline to prevent hyperchloraemic acidosis, except in specific contraindications.

    • Impact:

    • Highlights the importance of fluid composition in acid-base balance during resuscitation.
    • Informs clinical practice regarding the choice of intravenous fluids to avoid iatrogenic complications.
    • Contributed to the development of new fluid resuscitation strategies, like Hextend, using balanced solutions.