[Spinal growth under physiological and pathological conditions]
Related Experiment Video
Updated: Oct 1, 2026

A Microfluidic Platform for Stimulating Chondrocytes with Dynamic Compression
Published on: September 13, 2019
1Orthopädische Klinik, St. Josefs-Hospital Wiesbaden, Standort Mosbacher Strasse 10, 65187 Wiesbaden.
Abstract:
Spinal growth is developing analogously to extremity growth. As the vertebral spine is built by 25 "vertebral units" there are much more possibilities of compensatory growth in short parts of pathologic alterations than there are in cases of affected extremities that only show epiphyseal compensations in metaphyseal or diaphyseal deformities (such as juvenile fractures). The dynamics of growth is different in the spine. The neurocentral epiphysis, basis to seize of spinal channel, shows very strong dynamics in embryonal and early childhood growth corresponding to the development in central nerve system. Whereas, enchondral height growth of vertebral bodies does not end after puberty, in male sex even at about the age of eighteen. Enchondral growth of the spine is much more sensible to affections than periostal growth. This is analogous in the extremities. Spinal growth is determined genetically, but especially in puberty it can be influenced by the child's posture. This is a therapeutic hint especially for the period of fast vertebral growth in puberty. The strong straightening tendency of spine is fascinating. Thus, in the period of growth all spinal deformities are compensated by the vertebral segments below and above, so that the axis appears in horizontal line and the spine altogether in perpendicular position.
Related Concept Videos
Vertebral Column: Regions and Curvature
Regions of the Vertebral Column
In an adult, the spine is subdivided into five regions: the cervical, the thoracic, the lumbar, the sacral, and the coccygeal region. The spine initially develops as a series of 33 vertebrae; after 20 years of age, the nine bones in the sacral region, five sacral, and four coccygeal bones fuse to form the...
Nature and Nurture
Cellular Adaptation II: Hypertrophy
Changes in the Appendicular Skeleton with Age
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Degenerative Disc Disease I: Introduction
Degenerative Disc Disease ll: Pathophysiology

