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Lipid profile in children with insulin dependent diabetes mellitus

L M al-Naama1, M Kadhim, M S al-Aboud

  • 1Department of Biochemistry, College of Medicine, University of Basrah, Basrah, Iraq.

JPMA. the Journal of the Pakistan Medical Association
|April 20, 2002
PubMed

Insights

Children with type 1 diabetes exhibit elevated serum lipids, including total cholesterol and triglycerides, linked to glycemic control. Early screening and management are crucial for improving lipid profiles and overall health.

Area of Science:

  • Pediatrics
  • Endocrinology
  • Metabolic Disorders

Background:

  • Type 1 diabetes mellitus is a chronic condition affecting children.
  • Lipid abnormalities are a common complication in diabetic patients.
  • Understanding lipid profiles in pediatric diabetes is essential for long-term health.

Purpose of the Study:

  • To evaluate serum lipid levels in children diagnosed with type 1 diabetes mellitus.
  • To assess the relationship between serum lipids and glycemic control in these children.
  • To compare lipid profiles of diabetic children with age- and BMI-matched healthy controls.

Main Methods:

  • A study was conducted at Basrah Maternity and Children Hospital, Iraq.
  • Lipid profiles were analyzed in 32 children with type 1 diabetes.
  • Seventy-seven non-diabetic children were selected as controls.

Main Results:

  • Children with type 1 diabetes showed significantly higher levels of total cholesterol, triglycerides, HDL-C, LDL-C, VLDL-C, and LDL-C/HDL-C ratio compared to controls.
  • Age and BMI were comparable between diabetic and control groups.
  • No significant differences were observed in Apo O and Apo B levels between the groups.

Conclusions:

  • Significant lipid abnormalities are prevalent in children with type 1 diabetes and correlate with glycemic control.
  • Routine screening for serum lipids is recommended for children with type 1 diabetes.
  • Dietary management and insulin therapy can improve both glycemic control and lipid profiles.
Abstract

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