Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The aftermath of childhood hyperthyroidism.

M Segni1, C A Gorman

  • 1Department of Pediatrics, University La Sapienza, Rome, Italy. m.segni@mclink.it

Journal of Pediatric Endocrinology & Metabolism : JPEM
|April 20, 2002
PubMed
Summary

Long-term juvenile hyperthyroidism effects are mainly from treatments, not the condition itself. While some symptoms resolve, serious complications like agranulocytosis and surgical risks can occur.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Thyroid hormones act as mitogenic and pro survival factors in rat ovarian follicles.

Journal of endocrinological investigation·2018
Same author

Clinical relevance of thyroid-stimulating autoantibodies in pediatric graves' disease-a multicenter study.

The Journal of clinical endocrinology and metabolism·2014
Same author

Prevalence of activating thyrotropin receptor and Gsα gene mutations in paediatric thyroid toxic adenomas: a multicentric Italian study.

Clinical endocrinology·2013
Same author

Precocious puberty in two girls with Chiari I malformation: a contribution to a larger use of brain MRI in the diagnosis of central precocious puberty.

Minerva pediatrica·2010
Same author

Childhood Graves' ophthalmopathy: results of a European questionnaire study.

European journal of endocrinology·2005
Same author

Adult height in sixty girls with Turner syndrome treated with growth hormone matched with an untreated group.

Journal of endocrinological investigation·2005

Area of Science:

  • Pediatric Endocrinology
  • Thyroidology

Background:

  • Juvenile hyperthyroidism presents unique challenges in long-term management.
  • Consequences can stem from the hyperthyroid state or its therapeutic interventions.

Purpose of the Study:

  • To delineate the long-term sequelae of juvenile hyperthyroidism.
  • To differentiate between disease-related and treatment-related adverse outcomes.

Main Methods:

  • Review of existing literature on juvenile hyperthyroidism outcomes.
  • Analysis of adverse event data associated with antithyroid drugs, surgery, and radioiodine therapy.

Main Results:

  • Most hyperthyroid symptoms in children resolve with euthyroid state restoration.
  • Permanent adverse effects are primarily linked to treatments: 28% experience mild drug side effects; surgery carries risks of hypoparathyroidism (2%), cord paralysis (2%), and mortality (1/1000).
  • Radioiodine therapy's long-term risks are theoretical, though it can improve ophthalmopathy.

Conclusions:

  • Treatment, not the hyperthyroid state itself, is the primary driver of permanent adverse effects in juvenile hyperthyroidism.
  • Careful consideration of treatment risks is crucial for managing pediatric thyrotoxicosis.
  • Long-term consequences beyond established treatment morbidities remain largely uncharacterized.

Related Experiment Videos