Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Tuberculosis of the knee.

Eduard Bernard Hoffman1, John Allin, John Andrew Boyd Campbell

  • 1Department of Orthopaedics, University of Cape Town, Republic of South Africa.

Clinical Orthopaedics and Related Research
|April 20, 2002
PubMed
Summary

Radiologic staging of knee tuberculosis in children accurately predicts treatment outcomes. Early-stage disease (Stage 1 or 2) treated with chemotherapy alone shows excellent results, while advanced stages (Stage 3 or 4) have poorer outcomes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

RDNS and Bowls Australia team up to provide health education.

Australian nursing & midwifery journal·2016
Same author

Pediatric atlanto-occipital dissociation: radiographic findings and clinical outcome.

Evidence-based spine-care journal·2012
Same author

Supracondylar fractures of the femur in children: closed reduction and percutaneous pinning of displaced fractures.

Journal of pediatric orthopedics·2005
See all related articles

Area of Science:

  • Orthopedics
  • Pediatric Infectious Diseases
  • Radiology

Background:

  • Knee tuberculosis in children presents diagnostic challenges, especially differentiating it from pauciarticular juvenile rheumatoid arthritis.
  • Radiologic findings at presentation are crucial for predicting the prognosis of knee tuberculosis.

Purpose of the Study:

  • To evaluate the predictive value of initial radiologic appearance on treatment outcomes in pediatric knee tuberculosis.
  • To assess the effectiveness of antituberculous chemotherapy without synovectomy.
  • To investigate diagnostic challenges in differentiating tuberculosis from juvenile rheumatoid arthritis.

Main Methods:

  • Retrospective review of 52 children with knee tuberculosis treated between 1979 and 1999.
  • Analysis of radiologic findings at presentation, correlating them with treatment outcomes.

Related Experiment Videos

  • Histologic evaluation of synovial biopsy specimens and polymerase chain reaction (PCR) for Mycobacterium tuberculosis.

    • Main Results:

    • Radiologic stage at presentation was predictive of outcome.
    • 92% of patients had Stage 1 or 2 disease (synovitis) with normal joint space, achieving excellent/good results with chemotherapy alone.
    • Stage 3 and 4 disease with narrowed joint space resulted in fair/poor outcomes.
    • Synovial biopsy sensitivity for juvenile rheumatoid arthritis was 53%; PCR sensitivity for tuberculosis was 40%.

    Conclusions:

    • Initial radiologic assessment is a key factor in predicting outcomes for pediatric knee tuberculosis.
    • Antituberculous chemotherapy without synovectomy is effective for early-stage disease.
    • Diagnostic methods like synovial biopsy and PCR have limitations in sensitivity for differentiating knee conditions.