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Related Experiment Videos

Aspirin-induced rhinitis and asthma.

A Szczeklik1, E Nizankowska, M Sanak

  • 1Department of Medicine, Jagellonian University School of Medicine, Cracow, Poland. mmszczek@cyf-kr.edu.pl

Current Opinion in Allergy and Clinical Immunology
|April 20, 2002
PubMed
Summary

Aspirin-induced asthma, affecting 5-10% of asthmatics, involves nonsteroidal anti-inflammatory drugs triggering attacks. Biochemical analysis reveals leukotriene overproduction, with potential genetic links to severe disease.

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Area of Science:

  • Immunology
  • Pulmonology
  • Pharmacology

Background:

  • Aspirin-induced asthma is a distinct clinical syndrome where nonsteroidal anti-inflammatory drugs (NSAIDs) trigger rhinitis and asthma attacks.
  • This condition affects 5-10% of adult asthmatics and is often underdiagnosed.
  • A pan-European survey suggests a common pattern in the development of aspirin-induced asthma across Europe.

Purpose of the Study:

  • To describe the natural history of aspirin-induced asthma.
  • To investigate the biochemical underpinnings of aspirin-induced asthma.
  • To explore potential diagnostic and therapeutic advancements for aspirin-intolerant asthma patients.

Main Methods:

  • Conducted an extensive pan-European survey to describe the natural history.

Related Experiment Videos

  • Utilized aspirin provocation tests for diagnosis.
  • Analyzed biochemical markers, including cysteinyl leukotriene overproduction and LTC4 synthase expression and its genetic alleles.

    • Main Results:

    • Aspirin-induced asthma follows a characteristic pattern across Europe.
    • Diagnostic accuracy of aspirin provocation tests has improved, but in-vitro tests lack diagnostic value.
    • Chronic overproduction of cysteinyl leukotrienes, overexpression of LTC4 synthase in bronchi, and upregulated mRNA in eosinophils characterize the condition.
    • A specific LTC4 synthase gene allele is associated with severe, steroid-dependent aspirin-induced asthma.

    Conclusions:

    • Aspirin-induced asthma exhibits a consistent natural history and biochemical profile.
    • LTC4 synthase plays a key role in the pathophysiology of aspirin-induced asthma.
    • New cyclooxygenase-2 inhibitors show promise as a safe alternative for aspirin-intolerant asthma patients.