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Related Experiment Videos

Immunoglobulin E and its regulators.

D Vercelli1

  • 1Respiratory Sciences Center and Department of Cell Biology and Anatomy, College of Medicine, University of Arizona, Arizona 85724, USA. donata@resp-sci.arizona.edu

Current Opinion in Allergy and Clinical Immunology
|April 20, 2002
PubMed
Summary
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Toll-like receptor 6 gene (TLR6): single-nucleotide polymorphism frequencies and preliminary association with the diagnosis of asthma.

Genes and immunity·2004
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Learning from discrepancies: CD14 polymorphisms, atopy and the endotoxin switch.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2003
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CD14: an example of gene by environment interaction in allergic disease.

Allergy·2002
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A common single nucleotide polymorphism in the CD14 promoter decreases the affinity of Sp protein binding and enhances transcriptional activity.

Journal of immunology (Baltimore, Md. : 1950)·2001
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CD14: a bridge between innate immunity and adaptive IgE responses.

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IgE isotype determination: epsilon-germline gene transcription, DNA recombination and B-cell differentiation.

British medical bulletin·2001

New research highlights gene-environment interactions in IgE regulation and identifies activation-induced deaminase as crucial for antibody responses, advancing our understanding of immunoglobulin isotype expression.

Area of Science:

  • Immunology
  • Molecular Biology

Background:

  • Immunoglobulin E (IgE) regulation is complex, with gene-environment interactions influencing allergic responses.
  • Understanding the molecular mechanisms of antibody isotype switching is critical for immune response research.

Purpose of the Study:

  • To explore novel paradigms in IgE regulation.
  • To elucidate the molecular link between transcription and class switch recombination in antibody responses.

Main Methods:

  • Investigated gene-environment interactions in allergen-induced antibody responses.
  • Identified key molecular players in class switch recombination.

Main Results:

  • Gene-environment interactions significantly determine the type and amplitude of antibody responses.

Related Experiment Videos

  • Activation-induced deaminase, an RNA editing enzyme, is essential for class switch recombination.

    • Conclusions:

    • Findings strengthen the mechanistic connection between transcription and switching.
    • These discoveries are vital for understanding immunoglobulin isotype expression during immune responses.