Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sensitization and tolerance.

S Husby1

  • 1Department of Pediatrics, Odense University Hospital, Denmark. steffen.husby@ouh.fyns-amt.dk

Current Opinion in Allergy and Clinical Immunology
|April 20, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tracking of bone mass from childhood to puberty: a 7-year follow-up. The CHAMPS study DK.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2018
Same author

Prenatal pesticide exposure and PON1 genotype associated with adolescent body fat distribution evaluated by dual X-ray absorptiometry (DXA).

Andrology·2016
Same author

ESPGHAN position paper on management of percutaneous endoscopic gastrostomy in children and adolescents.

Journal of pediatric gastroenterology and nutrition·2014
Same author

Management guidelines of eosinophilic esophagitis in childhood.

Journal of pediatric gastroenterology and nutrition·2014
Same author

A practical guide for the diagnosis of primary enteric nervous system disorders.

Journal of pediatric gastroenterology and nutrition·2013
Same author

Diagnostic approach and management of cow's-milk protein allergy in infants and children: ESPGHAN GI Committee practical guidelines.

Journal of pediatric gastroenterology and nutrition·2012
Same journal

Biosimilars in allergology: an outline in pediatric patients.

Current opinion in allergy and clinical immunology·2026
Same journal

The immunogenetic landscape of systemic lupus erythematosus.

Current opinion in allergy and clinical immunology·2026
Same journal

Circadian control of innate immunity: molecular mechanisms and implications for allergic disorders.

Current opinion in allergy and clinical immunology·2026
Same journal

Probiotics in allergic disease: from adjunct supplement to immune-modifying strategy (2026 update).

Current opinion in allergy and clinical immunology·2026
Same journal

Updates on drug-induced anaphylaxis in children.

Current opinion in allergy and clinical immunology·2026
Same journal

Beta-lactam de-labelling as a core antimicrobial stewardship strategy in the era of the antimicrobial resistance pandemic: a narrative review.

Current opinion in allergy and clinical immunology·2026
See all related articles

This study explores immune tolerance in the gut, contrasting allergic sensitization with oral tolerance. Findings highlight the roles of specific cytokines and chemokines in maintaining tolerance and preventing allergic gastroenteritis.

Area of Science:

  • Immunology
  • Gastroenterology
  • Allergy Research

Background:

  • Allergic sensitization involves IgE-mediated and non-IgE-mediated immune responses, particularly in the gastrointestinal tract.
  • Oral tolerance represents the opposite of sensitization, crucial for preventing food allergies.
  • The global increase in asthma and allergies prompts investigation into immune system development and environmental factors.

Purpose of the Study:

  • To investigate the mechanisms underlying immune tolerance and allergic sensitization in the gastrointestinal tract.
  • To explore the roles of transforming growth factor beta, interferon gamma, eotaxin, and IL-5 in oral tolerance and allergic gastroenteritis.
  • To examine the influence of early life factors, such as breastfeeding and microbial exposure (hygiene hypothesis), on immune tolerance development.

Related Experiment Videos

Main Methods:

  • Development of a novel mouse model for eosinophilic allergic gastroenteritis using encapsulated dietary antigen.
  • Utilizing genetically modified mice with deletions in the eosinophil chemokine eotaxin or the cytokine IL-5.
  • Review of clinical allergy research and the 'hygiene hypothesis' concerning immune system maturation.

Main Results:

  • The experimental model demonstrated the critical importance of the eosinophil chemokine eotaxin in the pathogenesis of allergic gastroenteritis.
  • Transforming growth factor beta and interferon gamma were identified as key immunoregulatory cytokines in maintaining oral tolerance.
  • The 'hygiene hypothesis' is supported by data suggesting reduced microbial stimulation impacts T helper cell responses.

Conclusions:

  • Eotaxin plays a significant role in eosinophilic allergic gastroenteritis, indicating a potential therapeutic target.
  • Cytokines TGF-β and IFN-γ are vital for establishing and maintaining oral tolerance.
  • Breastfeeding and early microbial exposure are crucial determinants for developing clinical tolerance and preventing allergies in infancy.