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Drug metabolism in the skin
1Department of Dermatology, University Hospital, RWTH Aachen, Aachen, Germany. jensmalte.baron@post.rwth-aachen.de
Current Opinion in Allergy and Clinical Immunology
|April 20, 2002
Abstract:
The skin performs a wide range of active metabolic functions including xenobiotic metabolism involving metabolizing enzymes specific to the skin. In this review we focus on the role of drug metabolism: (i) in allergic reactions to substances of low molecular weight; (ii) in cutaneous vitamin A and D3 metabolism and its modulation; (iii) in the interaction of transport and metabolic enzymes in skin cells; and (iv) on novel tools for the measurement of drug metabolism in various compartments of the human skin.