Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Vaginal microbicides.

Sheena McCormack¹

¹MRC Clinical Trials Unit, 222 Euston Road, London NW1 2DA, UK. s.mccormack@ctu.mrc.ac.uk

Current Opinion in Infectious Diseases

|April 20, 2002

Summary

This summary is machine-generated.

This review covers challenges in evaluating microbicides, focusing on research from 2000-2001. It highlights how scientists addressed these difficulties in developing new microbicidal agents.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Understanding trial designs and acceptability of participation in an HIV vaccine trial with concurrent randomisation to oral pre-exposure prophylaxis in East and Southern Africa: a longitudinal qualitative study.

Trials·2026

Same author

Estimating HIV incidence and assessing associated risk factors among adults: Evidence from the 2018-2022 HIV vaccine preparedness cohort in Masaka, Uganda.

PloS one·2026

Same author

A Comparison of F/TAF and F/TDF as HIV Pre-Exposure Prophylaxis in a Predominantly Cisgender Women Population in East and South Africa: A Randomized, Factorial, Noninferiority Trial.

Journal of acquired immune deficiency syndromes (1999)·2026

Same author

HIV risk perception, trust and PrEP adherence among participants in an HIV prevention trial: a qualitative longitudinal study, South Africa.

BMJ open·2025

Same author

In danger: HIV vaccine research and development in Europe.

PLOS global public health·2025

Same author

Real-world experience of renal outcomes and management of PrEP users with estimated glomerular filtration rates less than 60 mL/min/1.73 m<sup>2</sup>.

Sexually transmitted infections·2025

Area of Science:

Microbiology and Infectious Diseases
Drug Development and Evaluation

Background:

Microbicides are crucial for preventing sexually transmitted infections.
Evaluating the efficacy and safety of new microbicides presents significant scientific hurdles.

Purpose of the Study:

To review literature from 2000 to August 2001.
To identify and discuss the challenges in evaluating candidate microbicides.
To present the innovative approaches used by researchers to overcome these evaluation challenges.

Main Methods:

Literature review of scientific articles published between 2000 and August 2001.
Analysis of studies focusing on the methodologies and outcomes of microbicide candidate evaluation.

Main Results:

Related Experiment Videos

Numerous challenges exist in the preclinical and clinical evaluation of microbicides.
Investigators have developed diverse strategies to address issues such as product stability, delivery methods, and ethical considerations in trials.
Standardized evaluation protocols are still evolving.

Conclusions:

The evaluation of microbicides is a complex, multidisciplinary endeavor.
Continued innovation in research methodologies is essential for advancing microbicide development.
Addressing the identified challenges is key to bringing effective microbicides to market.