Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Histological data in inflammatory myositis].

J Mikol1, M Polivka

  • 1Service Central d'Anatomie et de Cytologie Pathologiques, Hôpital Lariboisière, 2, rue Ambroise-Paré, 75475 Paris Cedex 10, France. jacqueline.mikol@lrb.ap-hop-paris.fr

Annales De Medecine Interne
|April 20, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Molecular and clinical diversity in primary central nervous system lymphoma.

Annals of oncology : official journal of the European Society for Medical Oncology·2022
Same author

IgG4-related disease and ANCA positivity: an overlap syndrome?

QJM : monthly journal of the Association of Physicians·2017
Same author

50-year-old man with a falcine mass.

Brain pathology (Zurich, Switzerland)·2017
Same author

[Central nervous system lymphoma revealed by lymphocytic meningitis in a patient with systemic lupus erythematosus: An unusual association].

La Revue de medecine interne·2016
Same author

[Chordoma].

Neuro-Chirurgie·2014
Same author

Diagnosis of follicular lesions of undetermined significance in fine-needle aspirations of thyroid nodules.

Journal of thyroid research·2013
Same journal

[Consensus Development Conference on Thrombosis and Pregnancy. 14 March 2003, Paris, France. Proceedings].

Annales de medecine interne·2004
Same journal

Kartagener's syndrome and renal failure.

Annales de medecine interne·2004
Same journal

Inflammatory pseudotumor of lymph nodes.

Annales de medecine interne·2004
Same journal

[Necrolytic migratory erythema revealing glucagonoma without diabetes].

Annales de medecine interne·2004
Same journal

[Bilateral primary non-Hodgkin's lymphomas of the adrenals].

Annales de medecine interne·2004
Same journal

[Acute "pseudo-angiocholitis" due to colonic adenocarcinoma in a man with primary sclerosis cholangitis and ulcerative colitis].

Annales de medecine interne·2004
See all related articles

Inflammatory muscular diseases like dermatomyositis, polymyositis, and inclusion body myositis are diagnosed via muscle biopsy. Inclusion body myositis presents unique neurogenic and myogenic features with protein aggregates.

Area of Science:

  • Neurology
  • Pathology
  • Rheumatology

Context:

  • Inflammatory myopathies encompass dermatomyositis (DM), polymyositis (PM), and inclusion body myositis (IBM).
  • Muscle biopsy is crucial for diagnosing these conditions by analyzing histological lesions.
  • These diseases can be linked to collagen disorders or preceding malignant tumors.

Purpose:

  • To detail the diagnostic significance of muscle biopsy in inflammatory muscular diseases.
  • To highlight the distinct characteristics of inclusion body myositis (IBM) within the spectrum of inflammatory myopathies.
  • To differentiate IBM from other inflammatory myopathies based on histological and clinical features.

Summary:

  • Muscle biopsy analysis reveals key histological features for diagnosing inflammatory muscular diseases, including DM, PM, and IBM.

Related Experiment Videos

  • Inclusion body myositis (IBM) is distinguished by neurogenic and myogenic features, and the presence of protein aggregates (beta-amyloid, tau, ubiquitin) in vacuoles.
  • Familial IBM shares histological traits with sporadic IBM, though inflammation may be less pronounced.

    • Impact:

    • Improved diagnostic accuracy for inflammatory myopathies through detailed histological analysis.
    • Enhanced understanding of the unique pathophysiology of inclusion body myositis, including its association with Alzheimer's-related proteins.
    • Provides a foundation for differentiating IBM and guiding further research into its pathogenesis and potential treatments.