[Drugs and closed-angle glaucoma risk]

Closed-angle glaucomas arise among predisposed patients (narrow iridocorneal angle) in response to various stimuli. Most of the attacks are of iatrogenic origin: all the topical and systemic mydriatic drugs can provoke an angle closure glaucoma attack. Dangerous active ingredients with closed-angle glaucoma are active substances with anticholinergic activity (peripheral action, central action, with anticholinergic side-effects), active ingredients with sympathomimetic alpha activity (alpha 1, alpha and beta with indirect effects), and the active ingredients with parasympathomimetic activity (anticholinesterases). The proprietary medicine, whether or not they are included in the French dictionary Vidal((R)), are classified according to the administration route and their different indications. The closed-angle glaucoma risk after administration of these drugs is noted in the items'contraindications and precautions in the summary of the product characteristics enclosed in the marketing authorization.