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Published on: July 6, 2016
Synthesis of aminoglycoside-DNA conjugates
I Charles1, Liang Xue, Dev P Arya
1Laboratory of Medicinal Chemistry, Department of Chemistry, Clemson University, Clemson, SC 29634, USA.
Bioorganic & Medicinal Chemistry Letters
|April 20, 2002
Abstract:
Development of aminoglycoside-nucleic acid conjugates is presented. Synthesis of a DNA dimer covalently linked to kanamycin and neomycin isothiocyanates has been carried out. The development of such conjugates will help couple the sequence specificity of nucleic acids to the electrostatic/shape complementarity of aminoglycoside antibiotics in binding nucleic acid targets.
