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Synthesis of a novel fluorescent probe for estrogen receptor
Maciej Adamczyk1, Rajarathnam E Reddy, Zhiguang Yu
1Department of Chemistry (9NM, Bldg AP20), Diagnostics Division, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064-6016, USA. maciej.adamczyk@abbott.com
Bioorganic & Medicinal Chemistry Letters
|April 20, 2002
Abstract:
A novel estradiol-mimetic fluorescent probe 5 was synthesized from diethylstilbestrol (DES, 1), which is useful for probing estrogen receptor (ERalpha), a prognostic indicator of estrogen-dependent cancers, and for developing a homogeneous fluorescence polarization (FP) assay to identify the ligands of estrogen receptor.