Related Experiment Videos
Novel diamide-based inhibitors of IMPDH
Henry H Gu1, Edwin J Iwanowicz, Junqing Guo
1Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543-4000, USA. henry.gu@bms.com
Bioorganic & Medicinal Chemistry Letters
|April 20, 2002
Abstract:
A series of novel amide-based small molecule inhibitors of inosine monophosphate dehydrogenase is described. The synthesis and the structure-activity relationships (SARs) derived from in vitro studies are presented.