Related Experiment Videos
Kinetics of cytokines and PMN-E in thoracoscopic esophagectomy
T Fukunaga1, A Kidokoro, M Fukunaga
1Department of Surgery, Urayasu Hospital of Juntendo University, School of Medicine, 2-1-1, Tomioka, Urayasu-shi, Chiba 279-0021, Japan. tetsu@med.juntendo.ac.jp
Background:
Perioperative increases in the levels of cytokines and polymorphonuclear leukocyte elastase (PMN-E) have been shown to be related to degree of surgical trauma.
Methods:
We measured the changes in levels of interleukin-6 (IL-6), interleukin-8 (IL-8), and PMN-E in the perioperative period in patients undergoing thoracoscopic esophagectomy (n = 15) and conventional transthoracic esophagectomy (n = 15) for thoracic esophageal cancer.
Results:
Both IL-6 and IL-8 increased markedly immediately after transthoracic esophagectomy and thereafter, but only a slight increase was observed after the thoracoscopic procedure (IL-6: p = 0.047; IL-8: p = 0.03). A difference was also seen in the pattern of changes in PMN-E. Levels of PMN-E increased immediately after transthoracic esophagectomy and continued to be high up to the 3rd postoperative day, but they remained low after the thoracoscopic procedure and showed no increase (p
Conclusion:
These results suggest that, compared with transthoracic esophagectomy, thoracoscopic esophagectomy results in less production of cytokines and PMN-E and thus causes less surgical trauma.