Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Developing soluble polymers for high-throughput synthetic chemistry.

Carsten Spanka1, Paul Wentworth, Kim D Janda

  • 1Department of Chemistry, The Scripps Research Institute and the Skaggs Institute for Chemical Biology, 10550 N. Torrey Pines Rd., La Jolla, CA 92037, USA.

Combinatorial Chemistry & High Throughput Screening
|April 23, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Redefining Drug Immune Recognition: A Radically Reconfigured Molecular Architecture Enables Broad Fentanyl-Class Protection.

Journal of medicinal chemistry·2026
Same author

Fentanyl-Rewired: A 2‑Azaspiro[3.3]heptane Core Preserves μ‑Opioid Function.

ACS medicinal chemistry letters·2026
Same author

Bifunctional Behavior of Conformationally Constrained Methamphetamine Analogs: Unexpected Heteroclitic Immune Response and Antagonist Effects Altering Methamphetamine and Fentanyl Pharmacology.

Journal of medicinal chemistry·2025
Same author

Solid-phase synthesis of a pyrrole library and identification of bioactive compounds.

Bioorganic & medicinal chemistry letters·2025
Same author

Bifunctional Inhibition of Botulinum Neurotoxin A Protease: Unexpected Active Site Inhibition Enhances Covalent Targeting of an Allosteric Site.

Journal of medicinal chemistry·2025
Same author

Discovery of GJG057, a Potent and Highly Selective Inhibitor of Leukotriene C4 Synthase.

Journal of medicinal chemistry·2025
Same journal

Mechanisms for Anti-Inflammatory Activity of Gold Nanoparticles.

Combinatorial chemistry & high throughput screening·2026
Same journal

Exploring Spectral Graph Theory in Combinatorial Chemistry.

Combinatorial chemistry & high throughput screening·2026
Same journal

Unveiling the Cellular and Molecular Insights into Ulcerative Colitis Pathogenesis through Integrative Multi-omics and Functional Experiments.

Combinatorial chemistry & high throughput screening·2026
Same journal

Integrated Multi-Omics Identification of Novel Diagnostic Biomarkers and Immunometabolic Therapeutic Targets in Osteoporosis via Machine Learning.

Combinatorial chemistry & high throughput screening·2026
Same journal

Exploration and Prospects of Core Research Hotspots in the Mechanisms of Traditional Chinese Medicine for Treating Digestive System Malignancies Based on Bibliometrics.

Combinatorial chemistry & high throughput screening·2026
Same journal

Investigating the Potential Pharmacological Mechanisms of Huangqi in Allergic Rhinitis Using Network Pharmacology and Molecular Docking Strategies.

Combinatorial chemistry & high throughput screening·2026
See all related articles

New soluble polymers offer alternatives to traditional resin supports in high-throughput chemistry. This study explores novel block copolymers, star polymers, and substituted poly(norbornylene)s to enhance solubility and loading capabilities.

Area of Science:

  • Polymer Chemistry
  • Organic Synthesis
  • High-Throughput Screening

Background:

  • Soluble polymers are increasingly used as alternatives to solid resin supports in organic chemistry.
  • Limitations in broad-spectrum solubility and polymer loading hinder the wider application of current soluble polymer supports.
  • Development of novel soluble polymers is crucial to overcome these limitations in high-throughput applications.

Purpose of the Study:

  • To introduce novel soluble polymer supports for advanced organic synthesis.
  • To address the limitations of solubility and loading in current polymer-supported chemistry.
  • To focus on the development of parallel libraries using specific polymer architectures.

Main Methods:

  • Synthesis of de novo block copolymers, specifically poly(styrene-co-chloromethylstyrene).

Related Experiment Videos

  • Development of PEG-stealth star polymers for improved solubility characteristics.
  • Preparation of substituted poly(norbornylene)s as novel soluble polymer supports.

    • Main Results:

    • Demonstrated the synthesis of diverse soluble polymer architectures.
    • Explored the potential of these new polymers for parallel library synthesis.
    • Highlighted the improved solubility and loading properties of the developed polymers.

    Conclusions:

    • The developed soluble polymers, including block copolymers, star polymers, and substituted poly(norbornylene)s, show promise for high-throughput organic chemistry.
    • These novel materials offer solutions to the current limitations in solubility and loading.
    • Further application of these polymers can advance parallel library synthesis and organic synthesis methodologies.