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[Cyclizine-intoxication in six children (author's transl)]
Padiatrie Und Padologie
|January 1, 1975
Summary
Accidental cyclizine hydrochloride overdose in young children caused severe symptoms like hallucinations and ataxia. Treatment is symptomatic; avoid histamine and other medications.
Area of Science:
- Pharmacology
- Pediatric Toxicology
Background:
- Cyclizine hydrochloride is an antihistamine primarily used for motion sickness.
- Antihistaminic drugs can cause adverse effects, especially in pediatric populations.
Observation:
- Six cases of moderate cyclizine hydrochloride intoxication were observed in children aged 2-4 years.
- Average ingested dose was 200 mg, with symptoms appearing 1-2 hours post-ingestion.
Findings:
- Key symptoms included excitement, incoordination, ataxia, athetoid movements, and severe hallucinations.
- Flushed faces and dilated pupils were noted, but dry mouth and hoarseness were absent.
- No convulsions were reported in the observed cases.
Implications:
- Highlights the potential for severe toxicity from cyclizine hydrochloride in young children.
- Emphasizes the need for symptomatic treatment and avoidance of specific medications like histamine, apomorphine, phenothiazines, and analeptics.