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Published on: November 4, 2010
[Epidemiologic and bronchologic aspects of chronic bronchitis in childhood (author's transl)]
Insights
Chronic and relapsing bronchitis in childhood affects 1.64%-3.06% of children. Most cases involve deforming bronchitis, with a good prognosis for many after treatment.
Area of Science:
- Pediatric Pulmonology
- Epidemiology
- Clinical Medicine
Context:
- Established a definition for chronic and relapsing bronchitis in childhood in the German Democratic Republic (G.D.R.) in 1969.
- Epidemiological studies in Dresden school children revealed a prevalence rate of 1.64% to 3.06% for this condition.
Purpose:
- To determine the prevalence, clinical findings, and prognosis of chronic and relapsing bronchitis in childhood.
- To investigate potential causative factors including malformations, bronchiectasis, bacteriology, immunoglobulin levels, and alpha-1-antitrypsin.
Summary:
- Bronchologic examinations of 274 children showed deforming bronchitis in 51% and tracheobronchial malformations in 16%. Bronchiectasis was infrequent (9%).
- Follow-up of 220 children with deforming bronchitis indicated improvement or normalization in 62% after treatment, with deterioration or progression to bronchiectasis in 22%.
Impact:
- Provides epidemiological data on childhood chronic and relapsing bronchitis in the G.D.R.
- Highlights deforming bronchitis as a common finding with a generally favorable prognosis following treatment.
- Identifies key areas for further research into causative factors and management strategies.
Abstract:
After establishing a suitable definition of chronic and relapsing bronchitis in childhood in the G.D.R. in 1969 corresponding epidemiologic studies carried out in school beginners and school children in Dresden revealed a prevalence rate of 1,64% to 3,06% for this disease. The analysis of bronchologic examinations of 274 children performed at the Pediatric Clinic of the Medical Academy Dresden during the last four years showed a deforming bronchitis as the most frequent finding in the bronchogram of 51% of the patients. Malformations of the tracheobronchial tree could be demonstrated in 16% of the children examined. The frequency of bronchiectases was at a very low level (9%) and showed a regression by the half as compared with former results. The results of bacteriological examinations of the bronchial secretion, quantitative analyses of the immune globulins in the serum and the bronchial secretion and the alpha-1-antitrypsin are discussed as causative factors for chronic and relapsing bronchitis in childhood. For assessing the prognosis of deforming bronchitis 220 children had a bronchologic follow-up examination in four bronchologic centers for children in the G.D.R. after a one or several years' dispensary treatment. An improvement or a normalisation of the findings could be demonstrated by means of the bronchogram in 62% of these patients, whereas a deterioration or a transition to bronchiectases was observed in only 22% of the patients.
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