Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Teratomas in childhood.

P M Bale, D M Painter, D Cohen

    Pathology
    |July 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    This study analyzed 107 pediatric teratomas, finding most benign. Internal sacrococcygeal and pelvic teratomas showed higher malignancy rates, with specific histological features noted.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The effects of HIV on cognitive and motor development in children born to HIV-seropositive women with no reported drug use: birth to 24 months.

    Pediatrics·1995
    Same author

    The metanephric blastema differentiates into collecting system and nephron epithelia in vitro.

    Development (Cambridge, England)·1995
    Same author

    The activation of a specific DNA binding protein by neutron irradiation.

    International journal of radiation oncology, biology, physics·1995
    Same author

    Psychotropic drug use in relation to psychiatric symptoms in community-living persons with Alzheimer's disease.

    Pharmacotherapy·1995
    Same author

    Appropriate and effective use of the NSI checklist and screens. An update on caring for the elderly by preventing malnutrition.

    Journal of the American Dietetic Association·1995
    Same author

    Intransal or intragastric immunization with proteosome-Shigella lipopolysaccharide vaccines protects against lethal pneumonia in a murine model of Shigella infection.

    Infection and immunity·1995
    Same journal

    Impact of the 2025 Endocrine Society clinical practice guideline on the diagnosis and management of primary aldosteronism for the clinical laboratory.

    Pathology·2026
    Same journal

    Cribriform intraductal carcinoma of the prostate may have a greater prognostic impact even than Gleason grade 5 conventional prostatic adenocarcinoma.

    Pathology·2026
    Same journal

    Bordetella pertussis: emerging epidemiology, diagnosis and management.

    Pathology·2026
    Same journal

    Development and validation of a real-time polymerase chain reaction for the detection of Haycocknema perplexum.

    Pathology·2026
    Same journal

    Recent advances in the understanding of TP53 in haematological malignancies.

    Pathology·2026
    Same journal

    Concurrent renal amyloid light chain amyloidosis, light chain crystalline podocytopathy and light chain proximal tubulopathy: a case report.

    Pathology·2026
    See all related articles

    Area of Science:

    • Pediatric Oncology
    • Surgical Pathology

    Background:

    • Teratomas are common pediatric tumors with variable behavior.
    • Understanding the relationship between teratoma location, histology, and malignancy is crucial for patient outcomes.

    Purpose of the Study:

    • To investigate the characteristics of pediatric teratomas, focusing on location, histological subtypes, and malignant potential.
    • To correlate tumor location and histological features with prognosis in pediatric teratomas.

    Main Methods:

    • Retrospective analysis of 107 pediatric teratoma cases.
    • Classification of teratomas based on location (sacrococcygeal, pelvic) and subtype (post-sacral, dumbbell, presacral).
    • Histopathological examination to identify benign and malignant features, including immature tissues and specific carcinoma types.

    Related Experiment Videos

    Main Results:

    • Out of 107 teratomas, 86 were benign and 21 malignant.
    • Sacrococcygeal and pelvic teratomas were most common (51 cases).
    • Malignancy risk increased with tumor invasiveness in dumbbell and presacral types; purely posterior tumors were benign.
    • Malignant teratomas were typically carcinomas with glandular, papillary, and clear-cell areas; metastases were similar.
    • Immature tissues in benign teratomas (neural, connective) did not worsen prognosis or lead to specific sarcomas.

    Conclusions:

    • Pediatric teratoma location and invasiveness are key indicators of malignancy risk.
    • Specific histological features in malignant teratomas (carcinomas) and benign teratomas (immature tissues) have distinct prognostic implications.
    • While rare, malignant transformation of initially benign teratomas can occur.