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Kinase regulation: competing phosphatases in JAK dephosphorylation
1Laboratory of Lymphocyte Signalling and Development, Molecular Immunology Programme, The Babraham Institute, CB2 4AT, Cambridge, UK.
Current Biology : CB
|April 23, 2002
Abstract:
The Janus kinases (JAKs) are essential for cytokine receptor signalling and their dephosphorylation represents a potent inhibitory mechanism. A new paper highlights the T-cell tyrosine phosphatase as an important JAK inhibitor.