Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Does coagulation differ between elderly and younger patients undergoing cardiac surgery?

Joachim Boldt1, Günther Haisch, Bernhard Kumle

  • 1Department of Anesthesiology and Intensive Care Medicine, Klinikum der Stadt Ludwigshafen, Bremserstrasse 79, 67063 Ludwigshafen, Germany. BoldtJ@gmx.net

Intensive Care Medicine
|April 23, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Retraction Note: Hydroxyethylstarch as a Risk Factor for Acute Renal Failure : Is a Change of Clinical Practice Indicated?

Drug safety·2026
Same author

Five seconds to safety: detecting and managing critical instability before structured handover in non-trauma patients.

Scandinavian journal of trauma, resuscitation and emergency medicine·2026
Same author

Saline versus balanced hydroxyethyl starch: does it matter? RETRACTION.

Current opinion in anaesthesiology·2025
Same author

Developing a Data Trust Model (Not Only) for Sleep Research: Conceptual Study and Quantitative Survey.

JMIR human factors·2025
Same author

Precipitation as key parameter for early oral drug absorption predictions, Part I: Acquisition of critical data.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences·2025
Same author

No Improvement.

Deutsches Arzteblatt international·2025

Elderly cardiac surgery patients exhibit altered coagulation before surgery, potentially increasing their risk of postoperative hemostasis issues. Further research is needed to determine the exact causes of this impaired coagulation.

Area of Science:

  • Cardiology
  • Hematology
  • Geriatrics

Background:

  • Cardiac surgery is increasingly performed on older populations.
  • Perioperative hemostasis differences between elderly and younger patients are not well understood.

Purpose of the Study:

  • To investigate perioperative hemostasis differences in elderly versus younger patients undergoing cardiac surgery.
  • To assess coagulation status using modified thromboelastography (TEG) at multiple time points.

Main Methods:

  • Prospective, observational study at a single urban university-affiliated hospital.
  • Compared 21 elderly (age >80) and 21 younger (age <60) patients undergoing elective aortocoronary bypass grafting.
  • Utilized modified thromboelastography (TEG) with intrinsic (InTEG), extrinsic (ExTEG), and fibrinogen (fibTEG) activators to measure coagulation time (CT), clot formation time (CFT), and maximum clot firmness (MCF).

Related Experiment Videos

  • Measurements taken pre-surgery, post-surgery, 5 hours post-surgery (ICU), and on postoperative day 1 (POD1).

    • Main Results:

    • Elderly patients had slightly higher blood loss.
    • Baseline TEG data differed significantly between groups, indicating pre-existing hypocoagulability in the elderly.
    • Post-surgery and ICU, both groups showed similar TEG alterations.
    • On POD1, TEG values approached baseline but remained different between elderly and younger patients.

    Conclusions:

    • Elderly patients undergoing cardiac surgery present with moderately altered coagulation pre-operatively.
    • These pre-existing alterations may predispose elderly patients to postoperative hemostatic complications.
    • The precise reasons for impaired coagulation in the elderly require further investigation.