[Corneal descompensation in patients with endothelial compromise treated with topical dorzolamide]

To investigate the possibility of corneal alterations in patients with long-term endothelial compromise with topical dorzolamide.

Retrospective descriptive study of 17 patients with penetrating keratoplasty and glaucoma associated with topical carbonic anhydrase inhibitor therapy, looking for coincidence with corneal alteration.

Classified by ethiology, type of glaucoma and control, recording previous ophthalmological surgeries, evolution time, complications and rejection episodes. Seven patients suffered a corneal decompensation, in three of them there were signs of true reject but only four cases had edema at the beginning of dorzolamide treatment, one of them recovering after stopping dorzolamide. Risk factors were previous cataract surgery, mainly aphakia, filtering surgery and previous vitrectomy.

Dorzolamide could have a potential negative effect on patients with endothelial compromise.